The upcoming high-level General Assembly Economic Crisis Summit, which will be held from 1-3 June in New York, will assess the crisis that has devastated the world economy and search for solutions that take into account the interests of all nations. “What we are trying to accomplish … is to ensure that the full impact of decisions that are made is analysed and understood,” Michael Clark, senior advisor to President Miguel D’Escoto, told a news conference. “So that countries which are most affected but have the least ability to influence the global policies and who also have the least ability to bail themselves out have a voice and a presence in these discussions,” added Mr. Clark.Solutions to tackle the crisis will not be found at the UN and “they won’t literally be in an outcome document or statement or communiqué,” but participants of the conference will have the “ability to have an impact on the global agenda.”Mr. Clark noted that some ideas, such as looking at the role of the international reserve currency in easing the strain on financial markets is now part of government dialogue thanks to a commission of experts convened by the UN and headed by Nobel Laureate for economics Joseph Stiglitz.“So we have an ability to exercise influence that isn’t limited to what is said, written or agreed here,” Mr. Clark said. “That said we’ve been working very hard to produce a statement that has some special characteristics.”The June conference will provide a stronger voice and greater participation for the emerging and developing world in the global decision making process, in particular in fixing the “deeper structural problems in the way we manage the global economy,” including restructuring the Bretton Woods institutions.“We had the emerging and developing world actually lending money to developed countries. We had unsustainable deficits and in some ways unsustainable surpluses accumulating and we need to get to the heart of those issues,” stressed Mr. Clark.“We’re not going to solve all these problems in year or even two but it’s time we took seriously the need to make this effort more inclusive and diverse.” 1 May 2009The global conversation aimed at finding solutions to alleviate the economic and financial turmoil enveloping markets around the world needs to widen participation to include poor and developing nations, a senior advisor to the President of the United Nations General Assembly said today.
MONTREAL — Bombardier’s chief executive took a 27% pay cut last year, the transportation giant said Friday.Pierre Beaudoin’s total compensation in U.S. dollars was worth nearly US$6-million, compared with $8.2-million in 2011, according to a regulatory filing ahead of the company’s annual meeting next month.The company founder’s grandson earned $1.4-million in base salary in 2012, compared with $1.29-million a year earlier.The 2011 number was for 11 months because the company changed its fiscal year-end to Dec. 31.In 2012, Beaudoin also received $2.45-million in share-based awards, $1.2-million in options, $761,100 in incentives and a $22,000 pension value.A year earlier, he received $3.3 million in share-based awards, $1.5-million in options, $1.57-million in incentives and $362,400 in pension value.The total compensation for Bombardier’s top five executives fell 19% to $17.9-million.Railway division president Andre Navarri was second highest at $3.9-million, down from $4.7-million in 2011.Aerospace president Guy Hachey followed at $3.8-million, compared with $4.4-million a year earlier.Chief financial officer Pierre Alary’s compensation decreased to $2.3-million from $2.8-million in 2011.The other named executive was senior vice-president Richard Bradeen who earned $1.8-million in 2012.Bombardier’s profits plummeted 29.8% to $588-million on $16.8 billion of revenues last year.On the Toronto Stock Exchange, Bombardier’s shares closed unchanged at C$3.93 in Friday trading.The Canadian Press
Closing TSX index: Open 15,843.97 Close 15,802.70 Low 15,797.83 High 15,866.82 Change -4.47 Volume 254,381,453 Value 4,360,576,727
Eye Ubiquitous/Press Association ImagesIf you’ve ever worked in an office next to some kind of construction site or tried to sunbathe in the back garden while your neighbour does DIY you’ll know what we mean.Stop all that thudding and knocking around we’ve got work to do!2. Chalk on the blackboardJulien Behal/PA Archive/Press Association ImagesThe line we all know is “nails on chalkboard” but when you were younger, the sound of chalk making that weird squeaky noise off the school blackboard was enough to make your toes curl for days.In fact just thinking about it has made our skin crawl.3. People singing constantlyEven if you have the range of a young Mariah Carey we don’t want to hear you sing along to every song on the radio or at random intervals throughout the day.And if you’re a bad singer please stop before we record your awful singing and play it back to you.We’re like this hearing you sing:4. Dogs barkingbryd33 / YouTubeWe love dogs, we really do but once they get into a barking frenzy we’re too busy wanting to wedge our fingers into our ears forever to like them anymore.Why do you have to ruin your own good work dogs? Why?5. Loud musicIf you’ve ever had to try and sleep near a busy pub or nightclub then the weird way music sounds when thumping away nearby will drive you to distraction.The worst thing is you can kind of hear the song but all you’ll really get is a thud, thud noise as the bass threatens to invade your skull.FOREVER.6. Alarmsvia The TenderThe wail of a car alarm that some fool has yet to come out and turn off is the distant cousin to the blaring music problem.All you hear is a drone so persistent that you become slightly crazed and struggle to think of a time when you didn’t hear a car alarm non-stop.Then the alarm (finally) stops and you can go back to normal.7. Cutlery WE LIKE TO think that we’re reasonable types.But there are certain noises that turn us into easily irritated teeth gnashing monsters and we can’t hide it anymore.1. Hammers and general power-tool noises arti person / YouTubeThe sound of a knife scraping off a plate is enough to drive even the quietest individual into an intense rage.It’s like that dreaded school days noise of the chalk on the blackboard but when you least expect it, at meal time when you should be having a ball.Terrible.8. Chewing Disney for Life / TumblrAnother moment that interrupt the bliss of a good feed is hearing the sound of other people chewing.The weird half-wheeze, half-chomping noise that people make while chewing sounds like some kind of monster has taken over the person in question.Loud chewing ruins lives. Honestly.9. Headphones noiseDakotiaskye / YouTubeIf you’re on public transport regularly you’ll be sick and tired of the noise of people’s music blaring from their headphones.It’s like there’s a voice in your head playing weirdly compressed Euro-dance or endless wailing guitar.Turn down your headphones and let us try and make it through our morning commute in peace, please.10. Dentist related noisesAndrew Milligan/PA Archive/Press Association ImagesWhether it’s the sound of the thing they use to clean their teeth with or some kind of drill they are going to place INSIDE YOUR MOUTH there are just so many horrific noises when you go to visit the dentist.11. SlurpingWe’re just going to put this out there but people who slurp excessively while drinking a cup of tea or similar are really, really, really, really, really horrible.It’s such an unsettling, icky noise.Scarlet for all involved.12. Babies cryingvia GifSoupWe understand that babies cry for a good reason 99% of the time but that doesn’t mean that the sounding of wailing child doesn’t make us want to roar “STOP CRYING IT’S GIVING ME AN UNSETTLING FEELING IN MY HEAD” when they carry on too long.Sorry.13. WhiningThe actual whining noise is horrific whether it’s a human being using it to be funny (you’re not funny) or a dog or cat doing the same.We can actually feel our ears begin to bleed just writing about it.Try getting through this video of a dog whining and see how long it takes before you want to break everything.jrsodajerk / YouTubeThings Taylor Swift doesn’t like>WATCH: Drag queen falls off the stage at The Dragon in Dublin>
A Vancouver woman unknowingly provided critical DNA information that led police to arrest a distant relative in a 39-year-old homicide case in Iowa.Brandy Jennings said her parents divorced when she was young, and she barely knew her father. Years after his death in 2009, she decided to try to find out more about his side of the family.Jennings’ mother purchased a DNA kit for her through Ancestry.com. She spit into the collection tube and mailed her saliva sample in May 2018. Once she received her results, she uploaded them to a public database, GEDmatch.com, and promptly forgot about it — until last week.That’s when she started getting notifications through Facebook asking if she were related to a Manchester, Iowa, man police arrested in December on suspicion of first-degree murder.“I’m like, ‘No, not that I know of,’ ” Jennings said.Police arrested 65-year-old Jerry Lynn Burns after a DNA sample connected him to the December 1979 killing of Michelle Martinko outside a J.C. Penney’s store in Cedar Rapids, Iowa. Martinko, an 18-year-old high school student, suffered 21 stab wounds, as well as defensive wounds to her hands consistent with a struggle inside her family’s car outside the store.Police worked with Parabon NanoLabs of Reston, Va., to connect a DNA profile from blood the killer presumably left on Martinko’s dress and inside her vehicle to people who have uploaded DNA information to the GEDmatch database. Police gradually created a family tree of the potential killer and eventually obtained a sample of Burns’ DNA after retrieving a straw he used to drink soda.
The former Reds player wishes he would have joined Manchester United instead; he only scored six goals in 80 appearancesForward El-Hadji Diouf joined Liverpool in 2002 after he showed a great performance with Senegal in the 2002 FIFA World Cup.He had a chance to go either to Manchester United, Barcelona or Liverpool.And the footballer chose to play with the Reds, appearing in 80 matches but scoring only six goals.Report: Origi cause Klopp injury concerns George Patchias – September 14, 2019 Divock Origi injury in today’s game against Newcastle is a cause for concern for Jurgen Klopp.Perhaps with one eye on Tuesday’s trip to Italy…When asked about what is the biggest regret of his professional career.“I would say, Liverpool,” he was quoted by Sky Sports.“Because if I had the chance again I would go to Manchester United or Barcelona. At the time they wanted me also.”
Fuel Card Services has introduced a voluntary benefits scheme to reward and engage its 300 employees.Through the scheme, staff will have access to practical and recreational perks, such as free spa days, Tastecards, mobile phone insurance and discounted gym memberships, as well as savings on cinema tickets, groceries and travel. New benefits will also be added to the platform regularly.The fuel card provider’s staff will be able to redeem the benefits via an online platform and smartphone app.Employees will also receive an occasional gift box filled with treats, such as snacks, beers and stress balls.The voluntary benefits programme, provided by Perkbox, has been introduced to reflect the organisation’s commitment to enhance its work culture.Russ Kenyon (pictured), head of group sales at Fuel Card Services, said: “Rewarding our hard-working staff is hugely important to us. We believe it speaks volumes about the culture of an organisation and its dedication to keeping staff both motivated and happy.“Everyone likes to receive perks and treats that not only help us enjoy life outside of work, as well as in work, but also goes some way into making salaries go further.”
TRENTON, N.J. (WSVN) — A Pennsylvania man is now a millionaire after winning the lottery — using numbers from a fortune cookie!Ronnie Martin drives to New Jersey every day for work, and often picks up lottery tickets during his commute.Martin has played the same numbers since he found them years ago on a slip of paper inside a fortune cookie, saying he liked the numbers and decided to stick with them. That dedication finally paid off in July.He bought tickets for the $543 million Mega Millions drawing on July 24th, and though he didn’t win the grand prize, he did get five numbers correct — which earned him a $1 million take.Martin and his wife Shirley say they plan to use the prize money to pay off their house and bills, then put the rest in savings.Copyright 2019 Sunbeam Television Corp. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Kelly Swihart, Petersburg’s Chief of Police, stands in front of one of the cells in the community jail. (Joe Sykes)Budget cuts to state troopers are taking place all over Alaska. But in small Southeast communities, like Petersburg, it’s a double whammy. That’s because community jails are also taking a hit. And the two are inextricably linked.Download AudioWhen you think of doing time, most people imagine something on a grand scale like out of the film “The Shawshank Redemption.” But the community jails in Southeast are a little different from that.Kelly Swihart is Petersburg’s Chief of Police. He shows me a cell block made up of two rooms lodged at the back of the Petersburg police station.He takes me into one of the cells.“We have two steel bunks with some mattresses here and over in the corner is a combination unit of a sink and a toilet. It’s pretty sparse,” he says.The maximum stay here is 15 days at the moment. After that an inmate will be transferred to a larger facility in Juneau or Ketchikan. The state troopers are responsible for the transportation of people from community jails. But there are no law enforcement troopers in Petersburg, and Swihart thinks the swingeing cuts to the state troopers program will make it difficult for them to move prisoners in good time.“The chain of command at the DOC and the department of public safety need to connect,” he said. “Right now we are only supposed to hold people for 15 days based on our facility set up so they’ve only got a couple of weeks to get em out.”And he says what makes it extra hard is the Department of Corrections has slashed the budget for community jails. In Petersburg, state funding fell from 320,000 dollars to $185,000. He’s put in a proposal which would limit the length of stay in Petersburg’s jail to 9 days. That would make it even harder for the state troopers to get there on time.“Cuts to community jails has been a great concern to Alaska state troopers,” said Colonel James Cockrell, the Director of Alaska State Troopers. He says he’s already seeing a backlash from police departments in small communities as the troopers do not have the budget anymore to act as effectively in moving prisoners.“We are the face of state government and we’re the ones interacting with local police departments and we’re the ones who are going to have to pick up the back load when they start reducing their services,” he says. “We’re starting to get an adversarial relationship with the small police departments.”And much of the issue here is about maintaining relationships. The Department of Corrections controls the budget for the jails while the Department of Public Safety deals with the State troopers. Alaska State Troopers are being told to cut a further $2.6 million this year. With both agencies making severe cuts Cockrell says they will have to start to prioritize services.“There might be occasions where we are not going to have the manpower to make the transport but more likely we’ll make the transport and a trooper won’t be able to respond to a call for service,” he tells me.This is something that really concerns Kelly Swihart but he thinks whatever happens the community jails need to stay open.“The state needs to have a jail here. We need to have that type of facility here in Petersburg,” he said. “Without that facility we would have a negative impact on our quality of life and it would negatively impact our public safety.”For the time being the jail here is safe. But Swihart says it might not be long before further cuts spell closing time for community jails across the state.
A white male tiger aged about 21 years and six months died at Nehru Zoological Park in Hyderabad on Monday night. The royal bengal tiger which was suffering from lameness caused by old age was kept away from display for the last five years, said a statement from zoo. The tiger was under intensive care at the summer house for the last three days. A team from college of veterinary science, Rajendranagar, LaCONES, CCMB and zoo conducted the autopsy and confirmed that the death was due to ‘senility-induced asphyxia’.
In a sign of relief to the government, gold imports came down drastically in December, 2014 after the rule mandating traders to re-export 20% of the gold import was scrapped.The trend continued in January as well, providing a boost to the government’s fight in maintaining the current account deficit (CAD) at a manageable level. ReutersTerming the import numbers for December and January ‘comfortable’, commerce secretary Rajeev Kher, on Wednesday, confirmed that the government was not looking at new import restrictions.Gold imports for December stood at 39 tonnes, against November’s 152 tonnes; continuing the trend, the first week of January saw gold imports at 7 tonnes.The months of September and October saw gold import touch 95.62 tonnes and 109 tonnes respectively, on the back of annual festival demand, threatening the CAD. However, the fall in oil prices cushioned the spike in imports.The 80:20 rule was introduced by the previous UPA government, mandating a compulsory re-export of gold, in a bid to control the CAD. However, the NDA government abolished the rule, rightfully so, diagnosing that the rule was distorting the market and increasing imports.On Wednesday, Kher met stakeholders to discuss issues pertaining to the industry and how the ‘Make in India’ drive could help. Financing and mining for the yellow metal was also discussed.With the scrapping of the 80:20 rule and with smuggling expected to come down, availability of gold for the domestic market would not be a problem, said Pankaj Parekh, vice-chairman, Gems and Jewellery Export Promotion Council.There is a need to bring people to stop investing in gold, he added, in a bid to help reduce the trade deficit. Rationalisation of duty drawback for gold jewellery exporters will be taken up by the government in the budgetary consultations with the ministry of finance, said Kher.Indians have traditionally seen the yellow metal as a bellwether investment and families hold gold mostly in jewellery form.
Close Amazon Debuts Its New, Cute Autonomous Delivery Robot Named Scout The year 2019 has been a good omen particularly for the technology companies. It began with arch-rivals Apple and Samsung announcing collaboration to support the former’s Apple TV series and AirPlay support on latter’s smart TVs. Earlier this week, Apple and Qualcomm ended a bitter patent infringement battle and forged a new agreement for modem supply for iPhones.Now, old foes Amazon and Google too have announced truce after two years of spat. In late 2017, both the companies took down each other’s services—YouTube and Amazon Prime Video—on Fire TV and Chromecast, respectively. Amazon went on to remove products such as Chromecast and other Google hardware off its e-commerce site.However, the bitterness between the two technolgy giants is all gone now. “We are excited to work with Amazon to launch the official YouTube apps on Fire TV devices worldwide. Bringing our flagship YouTube experience to Amazon Fire TV gives our users even more ways to watch the videos and creators they love,” said Heather Rivera, Global Head of Product Partnerships at Google YouTube, said. Google YouTube app coming soon too Amazon Fire TVAmazon.com (screen-shot)”We’re excited to bring the Prime Video app to Chromecast and Android TV devices, and to give our customers convenient access to the shows and movies they love. Whether watching the latest season of The Marvelous Mrs. Maisel, catching teams go head-to-head on Thursday Night Football or renting a new-release movie, customers will have even more ways to stream what they want, whenever they want, no matter where they are,” Andrew Bennett, Head of Worldwide Business Development for Amazon Prime Video said.There is no word on the timeline on when the Amazon services go live on Google Chromecast and Android TV, and Google service on Amazon devices, but it is said to be soon, most probably in a month or two. Google YouTube app for Amazon Fire TV is coming soon.ReutersUsers will be able to sign in to their existing YouTube account, access their full library of content, and play videos in 4K HDR at 60 fps on supported devices. In addition, standalone YouTube TV and YouTube Kids apps will also launch later this year on Fire TV devices and Fire TV Edition smart TVs where available.On the other hand, Android TV and Chromecast owners can soon login to the Amazon Prime Video service to access Amazon Originals like The Marvelous Mrs. Maisel, Hanna, Homecoming, Bosch, Catastrophe and The Grand Tour, several other hit TV shows such as Seinfeld, Two and Half Men, and scores of block buster Hollywood and other regional movies, as well.
Obaidul QuadeRoad, transport and bridges minister Obaidul Quader on Tuesday said the decision on the size of the election-time cabinet will be taken at a meeting on 26 October, reports UNB.A joint meeting of Awami League central working committee and its advisory parliamentary committees will be held at 6:00pm on the day to take the decision, Quader, also the AL general secretary, said while briefing newsmen at his secretariat office in the city.According to the prime minister’s Monday’s speech, he said, there is little possibility to downsize the cabinet.Prime minister Sheikh Hasina on Monday preferred not to downsize the cabinet ahead of the election for the sake of completing the ongoing crucial development projects.Quader also said, “If the size is smaller, two or more ministers can be added.”The meeting will also decide the declaration of the party manifesto for the upcoming general election, he added.”The Election Commission will declare the schedule for the upcoming national election by the first week of November,” the AL general secretary said.The EC will work to create a level-playing field and conduct the election in a free and fair manner, he said.”Who will contest the election to be decided by the commission,” said the AL leader.The duties of the election-time cabinet will be limited, said the minister adding, “It’ll do only routine works. There’ll be no ECNEC meeting, no bills will be passed, and no project will be inaugurated either at that time.”Responding to a query whether there will be any cabinet meeting, the minister said if the prime minister wants, cabinet meetings could be held. “But no agenda will be implemented at that time.”In other democratic countries of the world, normally elections are held under the government that are in power. “The same will happen in our country, too,” he said.Mainul’s arrestResponding to another question whether former adviser of a caretaker government Mainul Hosein was arrested for joining Oikya Front, Quader said, “He was arrested for abusing a female journalist, not for his political identity, but in a case filed against him … there is no political reason.”He asked the journalists just to forget that Mainul was arrested for his political identity.Digital Security Act amendmentWhile replying to a query on the Digital Security Act, the minister said there is no chance of any amendment to the much-debated act before the next general election.”We’ll keep it under observation if there is any misuse of the Act. If anyone doesn’t commit any crime, then why he would be worried about it,” he added.”A local AL leader filed a case against a woman of Jhenaigati upazila in Sherpur under the Act for distorting my photo on Facebook. When I heard about it, I asked the police to discharge her from the case,” said the minister.Grand alliance sizeResponding to another question whether the size of the grand alliance will be extended further, he said the decision will be finalised after observing other political alliances.Mega projectsAsked about the government’s previous promises that the mega projects would be completed during its current tenure, Obaidul said, “Mega projects like Padma Bridge and Metro Rail are now visible.”BNP and Jatiya PartyReplying to another question whether BNP will join the election, he said there will be level-playing during the election. “So, there is no need to invite them.”He also denied that there was any international pressure to invite them to join the election.Referring to Jatiya Party chairman’s HM Ershad’s recent speech on the election, Quader said, “As he (Ershad) is admitted to the CMH, he may fear about the election.””The election will be held on time,” the AL leader insisted.
President Barack Obama, center, with Maj. Gen. Michael S. Linnington, left, Commander of the U.S. Army Military District of Washington, during a wreath-laying ceremony at the Tomb of the Unknowns at Arlington National Cemetery on Memorial Day, Monday, May 28, 2012, in Arlington, Va. (Credit: ASSOCIATED PRESS)The Department of Defense’s Recognition and Commemoration of the Fallen Men and Women of the U.S. Armed Forces – 148th National Memorial Day Observance will occur on May 25 at 11 a.m. at the Arlington National Cemetery. Free parking is available in the welcome center’s parking garage. A presidential Armed Forces Full Honor Wreath-Laying Ceremony at the Tomb of the Unknowns followed by an observance program hosted by DoD in Arlington’s Memorial Amphitheater.
Facebook has disclosed another privacy breach: The company said Friday that a technical glitch in its photo-sharing system may have exposed the private photos of as many as 6.8 million users.The company said it fixed the bug in the photo application programming interface (API) that is used to let some 1,500 apps from 876 developers access Facebook users’ photos. The social giant said some third-party apps may have had access to a “broader set of photos than usual” for 12 days, between Sept. 13-25, 2018.Facebook said the only apps affected were those that the company approved to access the photos API. However, the glitch potentially gave developers access to photos that users did not agree to share, such as those posted on Marketplace or Facebook Stories, as well as pics people uploaded to Facebook but chose not to post. The disclosure comes after Facebook in late September announced the biggest hack in its history: The company reported that a security vulnerability had compromised up to 50 million user accounts. It later said hackers had successfully accessed data from 29 million Facebook members.That was after the news earlier this year that info on up to 87 million Facebook users was misappropriated by Cambridge Analytica, a data consultancy that was used by Donald Trump’s 2016 election campaign. That fiasco led to CEO Mark Zuckerberg testifying before congressional committees. And in August, Facebook said an app called myPersonality had improperly shared personal data from 4 million users with researchers and other third parties.On the photo issue, Facebook said it will notify users who were potentially impacted by the bug via an alert on the service, directing them to a Help Center page (at this link) to check if they’ve used any apps affected by the bug. In addition, the company recommends users log into any apps with which they have shared their Facebook photos to check which photos the apps have access to.“We’re sorry this happened,” Tomer Bar, engineering director at Facebook, wrote in a notice posted Friday to the company’s site for developers. “Early next week we will be rolling out tools for app developers that will allow them to determine which people using their app might be impacted by this bug.” He added that Facebook will work with those developers to delete the photos from affected users. Popular on Variety ×Actors Reveal Their Favorite Disney PrincessesSeveral actors, like Daisy Ridley, Awkwafina, Jeff Goldblum and Gina Rodriguez, reveal their favorite Disney princesses. Rapunzel, Mulan, Ariel,Tiana, Sleeping Beauty and Jasmine all got some love from the Disney stars.More VideosVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9Next UpJennifer Lopez Shares How She Became a Mogul04:350.5x1x1.25×1.5x2xLive00:0002:1502:15
Citation: Simple method for selective bioconjugation of native proteins (2015, April 16) retrieved 18 August 2019 from https://phys.org/news/2015-04-simple-method-bioconjugation-native-proteins.html © 2015 Phys.org Using DNA to assemble a protein lattice More information: “One step site-specific modification of native proteins with 2-pyridinecarboxyaldehyde” Nature Chemistry Biology published online: 30 march 2015. DOI: 10.1038/nchembio.1792 The next step was to optimize the reaction conditions to make this an easily adaptable bioconjugation reaction. MacDonald et al. used RNase A as a model protein substrate, and included additives to the reaction mixture to replicate the chemistry of the protein surface. They found that RNase A was selectively modified at the N-terminus with optimal conditions at 10 mM 2PCA in 50 mM phosphate buffer at pH 7.5 and 37oC for 16 hours. Protein concentration played little role in the success of the reaction, and the reaction tolerated a variety of buffers without interacting with the additives.After optimizing the 2PCA reaction, the next step was to modify 2PCA with functional groups that are of interest for bioconjugation reactions. Other studies have shown that an acylation reaction with 2PCA and N-hydroxysuccinimide (NHS) esters have worked well as a straight-forward way to modify 2PCA. MacDonald et al. were able to make protein-PEG bioconjugates using 2PCA-PEG. Characterization studies showed no side products due to non-site-specific reactions.Importantly, this reaction worked well for a variety of commercially available proteins, including those with free cysteines. The authors tested their procedure with aldolase, a homotetramer with eight free cysteines per subunit. They were able to successfully modify the N-terminal group as well as selectively modify two of the eight free cysteines. They were also able to successfully modify 2PCA using a variety of substrates that might be of interest for protein modification.The next question is whether the secondary and tertiary structures affect the 2PCA modification of the N-terminal group. Since a key part of the reaction is the formation of the cyclic imidazolidinone, steric hindrance from the three dimensional conformation of the protein may affect reactivity. They compared the reactivity of lysozyme and its N-terminal peptide analog. They found that the peptide was more reactive than the intact protein, confirming that access to the N-terminal group is an important factor in reactivity.Finally, this procedure was used to modify estrogen receptor alpha (ERα’), a receptor that binds selectively to estrogen. This is of interest because of recent concerns over drinking water contaminated with certain hormone disruptors. ERα’ was modified with 2PCA-biotin using the reported procedure, producing the bioconjugated product in 80% yield. The biotinylated ERα’ was immobilized on a streptavidin resin and loaded with fluorescent ethinyl estradiol. In the presence of ethinyl estradiol, the fluorescent reporter is released from the binding site and detected by fluorescence spectroscopy. This demonstrates that the ERα’ maintained its functionality even after modification, and it demonstrates a relatively simple method that might be used for detecting hormone disruptors in drinking water. Overall, this method is a simple, mild reaction that is adaptable to a diverse set of proteins. Furthermore, it works with native proteins without the need for genetic modification, does not seem to compromise protein functionality, and is site-specific even in the presence of highly reactive amino acids. Journal information: Nature Chemical Biology Ways to work around this problem include genetically engineering parts of the protein, but this can lower proteins expression levels, or devising a reaction scheme that is specific to a particular target on a protein; however, this is often complex, low yielding, and not scalable. James I. MacDonald, Henrik K. Munch, Troy Moore, and Matthew B. Francis of the University of California at Berkeley may have a solution. They have devised a general method for site-specific modification of the N-terminal portion of the protein that is mild, versatile, scalable, and does not require genetic engineering. Their work is presented in Nature Chemical Biology.Many of these amino acids on the protein surface have reactive functional groups that will react with a substrate, even if the substrate is designed to target a different site. For example, cysteine has a thiol side chain. The thiol is highly reactive, which is helpful for many bodily processes, but makes selective chemical modification in the presence of a free cysteine difficult. One site of interest for protein modification is the N-terminus part of the protein. This free amine is able to undergo various reactions, such as acylation. However, most reactions involving the N-terminus are multi-step and are often specific to certain N-terminal amino acids. MacDonald et al.’s simple, one-step reaction expands on this work by selectively modifying the N-termini of a variety of proteins.Their first step was to identify the right substrate to react with the free amine. Prior studies had shown that several types of aldehydes react with the N-termini to form 1:1 condensation products. Aryl aldehydes, specific derivatives of pyridinecarboxaldehydes, offer better site specificity because they form a cyclic imidazolidinone with the N-terminal amine and the neighboring amino acid. While a series of aryl aldehydes were tested as potential candidates for the modification of the N-termini of angiotensin I, 2-pyridinecarboxaldehyde (2PCA) offered the best yields under mild conditions. Further studies verified that 2PCA selectively reacted with the N-terminus of angiotensin I and that neighboring amino acids had little effect on reactivity. Further studies using these reaction conditions revealed that all possible N-terminal amino acids showed excellent yields, with proline and glycine as the least reactive. Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Whether it is for pharmaceuticals, or imaging, or proteomics, many scientists are interested in finding better ways to chemically tweak proteins. However, proteins are chemically complex, and targeting one particular place on the protein surface without also chemically modifying the surrounding amino acids can be tricky.
The report mainly studies the size, recent trends and development status of the Needle Pressure Gauge market, as well as investment opportunities, government policy, market dynamics (drivers, restraints, opportunities), supply chain and competitive landscape. Technological innovation and advancement will further optimize the performance of the product, making it more widely used in downstream applications.The report begins with a brief introduction and market overview, in which the Needle Pressure Gauge industry is first defined before estimating its market scope and size. Next, the report elaborates on the market scope and market size estimation. This is followed by an overview of the market segmentations such as type, application, and region. The drivers, limitations, and opportunities are listed for the Needle Pressure Gauge industry, followed by industry news and policies.Download Sample Copy @ https://www.bigmarketresearch.com/request-sample/3211783?utm_source=ANIL-HTNThe report also offers reliable and veracious market forecasts derived after deeply analyzing historical and current occurrences in the market. The report considers market trends, dynamics, growth drivers, influential factors, revenue, market size, and share and offers forecast up to 2024. The study helps to unveil present and upcoming market opportunities, challenges and improve the chances of Needle Pressure Gauge business growth. It also aids in reducing the intensity of uncertainties and risks that could affect market growth.The global Needle Pressure Gauge market has been segmented into vital divisions such as types, applications, regions, technology, and end-users. The report discusses each market segment at a minute level considering their market acceptance, attractiveness, revenue outcome, growth prospects, market trends, and volatile consumption tendencies. The analysis provides a market astute to market players that allow them to determine remunerative segments and the actual target size for their Needle Pressure Gauge business.The report is a compilation of first-hand information, qualitative and quantitative assessment by industry analysts, inputs from industry experts and industry participants across the value chain. The report provides in-depth analysis of parent market trends, macro-economic indicators and governing factors along with market attractiveness as per segments. The report also maps the qualitative impact of various market factors on market segments and geographiesFor the future period, sound forecasts on market value and volume are offered for each type and application. In the same period, the report also provides a detailed analysis of market value and consumption for each region. These insights are helpful in devising strategies for the future and take necessary steps. New project investment feasibility analysis and SWOT analysis are offered along with insights on industry barriers. Research findings and conclusions are mentioned at the end.Avail Discount on Report @ https://www.bigmarketresearch.com/request-for-discount/3211783?utm_source=ANIL-HTNTable of ContentsChapter 1 provides an overview of Needle Pressure Gauge market, containing global revenue, global production, sales, and CAGR. The forecast and analysis of Needle Pressure Gauge market by type, application, and region are also presented in this chapter.Chapter 2 is about the market landscape and major players. It provides competitive situation and market concentration status along with the basic information of these players.Chapter 3 provides a full-scale analysis of major players in Needle Pressure Gauge industry. The basic information, as well as the profiles, applications and specifications of products market performance along with Business Overview are offered.Chapter 4 gives a worldwide view of Needle Pressure Gauge market. It includes production, market share revenue, price, and the growth rate by type.Chapter 5 focuses on the application of Needle Pressure Gauge, by analyzing the consumption and its growth rate of each application.Chapter 6 is about production, consumption, export, and import of Needle Pressure Gauge in each region.Chapter 7 pays attention to the production, revenue, price and gross margin of Needle Pressure Gauge in markets of different regions. The analysis on production, revenue, price and gross margin of the global market is covered in this part.Chapter 8 concentrates on manufacturing analysis, including key raw material analysis, cost structure analysis and process analysis, making up a comprehensive analysis of manufacturing cost.Chapter 9 introduces the industrial chain of Needle Pressure Gauge. Industrial chain analysis, raw material sources and downstream buyers are analyzed in this chapter.Chapter 10 provides clear insights into market dynamics.Chapter 11 prospects the whole Needle Pressure Gauge market, including the global production and revenue forecast, regional forecast. It also foresees the Needle Pressure Gauge market by type and application.Chapter 12 concludes the research findings and refines all the highlights of the study.Chapter 13 introduces the research methodology and sources of research data for your understanding.About Us:Big Market Research has a range of research reports from various publishers across the world. Our database of reports of various market categories and sub-categories would help to find the exact report you may be looking for.We are instrumental in providing quantitative and qualitative insights on your area of interest by bringing reports from various publishers at one place to save your time and money. A lot of organizations across the world are gaining profits and great benefits from information gained through reports sourced by us.Contact us:Mr. Abhishek Paliwal5933 NE Win Sivers Drive, #205, Portland,OR 97220 United StatesDirect: +1-971-202-1575Toll Free: +1-800-910-6452E-mail: firstname.lastname@example.org
The growth of the global gynecological cancer drugs market is driven by factors such as high incidence of gynecological cancers, growth in importance of targeted drug therapies, increase in investment from government, public & private organizations for the development of novel drugs to treat cancer, and increase in risk factors that lead to cancer. However, the market growth is hampered by high cost of drug development and threat of failure & adverse effects of cancer drug therapy. Conversely, advancement of cancer drug research and advent of personalized medicine approach are expected to provide numerous opportunities for market growth during the forecast period.The global gynecological cancer drugs market was valued at $9,269 million in 2016, and is expected to reach $16,107 million by 2023, growing at a CAGR of 8.1% from 2017 to 2023.Download Report Sample with statistical info @ https://www.alliedmarketresearch.com/request-sample/3411Cancer progresses when normal body cells transform into abnormal cells and continue to grow in an uncontrolled manner. It is named after the body part in which it originates; thus, gynecological cancer refers to a group of cancers that affect the reproductive organs of a female, such as uterus, endometrium, ovary, peritoneum, fallopian tubes, vagina, vulva, cervix, and muscle & tissue supporting the uterus.The cervical cancer segment is expected to maintain its dominant position during the analysis period, owing to increase in prevalence of cervical cancer globally.Targeted therapy segment is expected to grow rapidly, registering a CAGR of 8.9% throughout the forecast period, owing to increased benefits of targeted therapy over chemotherapy.Gynecological Cancer Drugs Market SegmentationThe global gynecological cancer drugs market is segmented on the basis of therapeutic modality, indication, and region. Based on therapeutic modality, the market is divided into chemotherapy, targeted therapy, and hormonal therapy. The indications segment is categorized into uterine cancer, ovarian cancer, vaginal & vulvar cancer, and cervical cancer. Geographically, the market is analyzed across North America (U.S., Canada, and Mexico), Europe (Germany, France, Italy, UK, Spain, and rest of Europe), Asia-Pacific (China, Japan, Australia, India, South Korea, and rest of Asia-Pacific), and LAMEA (Brazil, South Africa, Saudi Arabia, and rest of LAMEA).Make an Enquiry for Promocode Of Discounted Price at: https://www.alliedmarketresearch.com/purchase-enquiry/3411Segment ReviewChemotherapy segment accounted for the largest market share in 2016, and is expected to maintain this trend throughout the forecast period. In recent years, combination chemotherapy is considered as a standard treatment mode for treatment of cancer due to its effectiveness in increase in survival & remission rates. For instance, combination therapy of gemcitabine with a platinum compound produced high response rates (as high as 71%) in patients suffering from ovarian cancer. Similarly, gemcitabine is used in combination with other compounds and cytotoxic agents for effective treatment of ovarian cancer. Popular combinations include gemcitabine with a platinum compound and paclitaxel, and gemcitabine with cisplatin or carboplatin. However, the standard approach of combination chemotherapy for treatment of epithelial ovarian cancer includes combination of a platinum compound, such as cisplatin or carboplatin, and a taxane, such as paclitaxel (Taxol) or docetaxel (Taxotere).Key Findings Of Gynecological Cancer Drugs Market:The chemotherapy segment accounted for nearly two-thirds share of the global market in 2016.Cervical cancer segment accounted for more than two-fifths share of the market in 2016.The ovarian cancer segment is expected to grow at the fastest CAGR of 10.0% from 2016 to 2022.Asia-Pacific is expected to be the fastest growing region, registering a CAGR of 9.8% during the forecast period.North America accounted for more than one-third share of the global market in 2016, and is expected to remain dominant throughout the forecast period. This is attributed to the increase in cancer incidence, growth in geriatric population, rise in patient awareness about the availability of treatment options, and favorable reimbursement framework for cancer drugs in the region. In addition, high adoption rate of cancer drugs and presence of highly sophisticated healthcare infrastructure are expected to present new growth opportunities to the players in this market.Access Full Summary at: https://www.alliedmarketresearch.com/press-release/gynecological-cancers-drugs-market.htmlAbout Us:Allied Market Research (AMR) is a full-service market research and business-consulting wing of Allied Analytics LLP based in Portland, Oregon. Allied Market Research provides global enterprises as well as medium and small businesses with unmatched quality of “Market Research Reports” and “Business Intelligence Solutions”. AMR has a targeted view to provide business insights and consulting to assist its clients to make strategic business decisions and achieve sustainable growth in their respective market domain.We are in professional corporate relations with various companies and this helps us in digging out market data that helps us generate accurate research data tables and confirms utmost accuracy in our market forecasting. Each and every data presented in the reports published by us is extracted through primary interviews with top officials from leading companies of domain concerned. Our secondary data procurement methodology includes deep online and offline research and discussion with knowledgeable professionals and analysts in the industry.Contact:David Correa5933 NE Win Sivers Drive#205, Portland, OR 97220United StatesUSA/Canada (Toll Free):+1-800-792-5285, +1-503-894-6022, +1-503-446-1141UK: +44-845-528-1300Hong Kong: +852-301-84916India (Pune): +91-20-66346060Fax: +1(855)email@example.com Gynecological Cancer Drugs Market
Share Tweet Submit Today, we have a new bunch of smartwatches in store which are offered in a massive discount for a limited time. Our discount on smartwatches brings new additions like the Huawei GT, Amazfit Bip and many more. If you want to compliment your smartphone and enhance its functionality, be sure to get one from the list. Let’s dive in to see some more details on the discount on smartwatches.Discount on Smartwatches – Includes the Amazing Amazfit Bip Lite, Huawei GT and more – Limited Quantities!Before we head over to the list. we would like to direct your attention to the limited availability of the discount on smartwatches. This means that if you wait for too long to order, the price drop will revert back to its original model. Henceforth, remember to order your share as soon as you can if you want to avail the discount.Oukitel W2 SportsMain Features:● Display Health ParametersThis smart wristband can display the time, date, steps, distance and calories clearly. Let you know your sports data immediately● Sync Sports DataWhen Bluetooth paired your smartphone, you can sync your data to the Android phone and iOS phone. It gives you a real-time assessment of your exercise throughout the day● Sleep MonitorAre you curious about your sleep quality? Sleep monitor function will give you the answer● Heart rate monitorHRM heart rate monitor function will give you the real-time feedback, let you know about your heart rate anytime and anywhere● Remote cameraThe Oukitel W2 Sports watch is a new addition to our list which boasts a majority of the features that you look for in a flagship smartwatch. It features a squarish design, which provides you with more screen real estate. If you’re interested in getting the Oukitel W2 Sports Watch, it is available at a hefty 31 percent off as part of our list of discount smartwatches. This makes the price jump down to just $27.99. Head over to this link to get it.Lenovo HX03FMain Features● This fitness tracker can be used to check your heart rate automatically and keep on monitoring it.● You can also track your workouts with ease including calories burnt, steps taken, distance covered and can also provide you with daily, weekly, monthly and even yearly statistics.● It is waterproof and can be used in the humid and wet condition. It has a waterproof rating of IP68.● You can use it as a calorie counter as well so that you know exactly how much calories you have burnt throughout the day so that you can stick to your fitness routine more easily.● You can synchronize your phone ( Android and iOS ) with this fitness tracker using the App “Lenovo Healthy” and can view your notifications like calls, SMSs and others on your fitness tracker.The Lenovo HX03F is one of our hot selling watches as part of our discount on smartwatches. It includes all the health and fitness related features along with other bits in a single hub. In addition, it has a compact design, which is easy on your wrists. If you’re enticed to own the Lenovo HX03F, it is available at an insane discount of 32 percent, which brings the price down to just $22.99. Head over to this link to get it. Xiaomi Amazfit Bip LiteMain Features:● Bluetooth 4.0Stable and fast to connect with your smartphones via Bluetooth function● Heart Rate MonitorMonitor your heart rate to provide accurate data for you anytime anywhere● GPS + GLONASS dual positioningEasy to show your exact position to assure your safety● Calls and APP Message ReminderRemind you of incoming calls and messages via vibration, you will never miss the important moments● Sleeping MonitoringCarefully monitor your sleep quality and help you develop good living habits, moreOne of my personal favorites, the Amazfit Bip Lite has the potential to replace any smartwatch. It features all and forgoes only a few aspects. The Amazfit Bip Lite is a must-have for everyone and it just brings everything to your wrist, which is the beauty of it. If you’re interested in owning the Amazfit Bip Lite, it is available at an insane 24 percent off, which brings the price down to just $69.99. Head over to this link to get it.Alfawise H19Main Features:● NFC analog IC door card, after the smart door lock writes data to the wristband, you don’t have to care if you forget to carry the door card● Daily sports activity tracking, built-in pedometer, calorie data, synchronized mobile phone GPS, moving distance, multiple sports mode records, etc. Break your own records every day● Real-time health monitoring – heart rate, blood pressure, blood oxygen and sleep monitoring to take care of your health● Portable extensions for smartphones, never miss a call. Call reminder, one-click rejection, information push, remote shutter, etc.● 1.3 inch 240 x 240 TFT color display for full display of multiple text messages● IP67 waterproof, no need to worry about sweating or rainy days, swimming● 180mAh lithium-ion battery, working time is up to 10 days, standby time is 30 days after charged for 2 hours● Different dial styles and colors to choose, free combinationThe Alfawise H19 is a great option and now that it is part of our discount on smartwatches, there’s no reason not to get it. It features a color display and boasts all the necessary bits that you’re looking for. If you’re up for it, the Alfawise H19 is available at a 21 percent discount, making the price come down to just $21.99. Head over to this link to get it.Huawei GTMain Features:• 1.39 inch AMOLED big screen• 24 hours heart rate monitor• Sports trail record• Sleep monitoring function to monitor your sleep quality• 420mAh polymer lithium battery for long time useThat’s right, we’re saving the best for last. The Huawei GT is the best option on our list of discount on smartwatches. The band is stylish and the watch itself boasts high-end features, competing against the giants of the industry. If you’re interested in getting the Huawei GT smartwatch for yourself, it is available at a massive 22 percent discount. This makes the price come down to just $189.99. Head over to this link to get it.This is all for our list of discount on smartwatches. If you’re interested, be sure to place an order as soon as you can. If you fail to do so, the discount on smartwatches will revert back to its original model. So do act fast. Also, do check out our massive discount on budget smartphones.That’s all for our list, folks. Are you willing to get the Huawei GT or the Amazefit Bip Lite? Let us know in the comments.
Travelweek Group What do you think of the new name for Virgin Voyages’ first ship? Tags: Preview, Scarlet Lady, Virgin Group, Virgin Voyages Posted by GENOA — Virgin Voyages has announced the name of its first ship and just like the cruise line itself, it’s definitely different.“The Scarlet Lady. There … we said it. The mermaid’s out of the bag! Scarlet is the embodiment of everything this ship represents. As our figurehead, she takes on a role historically dedicated to goddesses, important women in society, and even mermaid figures,” says the company. Set to launch in 2020, the adults-only Scarlet Lady is currently under construction at Fincantieri shipyard. The steel-cutting for the line’s as-yet-unnamed second ship, due for delivery in 2021, will take place soon.Render of the VIP DeckThe cruise line says the fleet’s branding dovetails with the company’s efforts to encourage front-facing female leaders with its Virgin Voyages Scarlet Squad Program. “From engineers to builders, marine tech to crew captains and technical positions, this program is meant to help female leaders break through the glass ocean if you will; it’s meant to create more leadership positions for women on the operations side of the sea travel industry. The multi-pronged approach, supported by skill development, recruitment and mentoring, is something we find incredibly important in areas traditionally lacking female leadership, like marine technical and hotel management.”Render of the elevated Mexican RestaurantVirgin Voyages adds: “All in all, ship is really coming together, quite literally, and more beautifully than we even expected. We can’t wait to see her in final form, but we know that no matter where we go, onboard or on land, our travel is graced by Scarlet’s presence in all of her glorious spontaneity. It’s an aura that permeates everything.”Onboard amenities in keeping with the line’s ‘Vitamin Sea’ ethos include: The Redemption Spa, the satellite mani-pedi spa, the Stubble & Groom barber shop and Dry Dock blow out barRender of The DockActive spaces designed for workouts, recoveries and socializing, from the B-Complex, complete with The Burn, Build, Balance and Bike rooms, to The Beast apparatus for a complete sweat. There’s also a Well-Being Pool adjacent to the Gym & Tonic Bar for socializingThe Athletic Club, with a history rooted in athletic social clubs of the past, incorporates an active Training Camp room and boxing classes as well as a full basketball court and a cold-pressed juice barRender of The Athletic ClubA catamaran net for passengers who want to “sit back and watch it all happen from the comforts of the largest daybed at sea”. All of this is situated under a Virgin red sky track called The RunwayThe Crow’s Nest provides a yoga, meditation and stretch-based space on the upper level deck << Previous PostNext Post >> Friday, July 20, 2018