Category: prwmnpcp

Category: prwmnpcp

first_imgAt a Harvard-sponsored panel Thursday at Boston City Hall Plaza, a group of top doctors and researchers discussed some remarkable developments in cancer treatment.Paraphrasing a recent statement by Harvard Medical School Dean George Q. Daley, event moderator Stanley Shaw, associate dean for executive education at HMS, said that recent advances in targeted and immunotherapy cancer treatments represent some “of the most breathtaking molecule-to-man stories in modern medicine.”The panel, “Deep Dive: Voices of Oncology Discovery,” was co-sponsored by Harvard University and HMS in partnership with The Boston Globe, Massachusetts General Hospital (MGH), and Bristol-Myers Squibb Co. It was presented as part of HUBweek, a series of panels and discussions designed to spotlight innovation.One panelist shared d a dramatic success story for targeted therapy. Linnea Olson, a local artist and blogger, became ill with non-small-cell lung cancer in 2005. Initially she was misdiagnosed with asthma and her cancer progressed for two years before she sought new treatment. A fortunate connection brought her to MGH, where she met Thomas Lynch Jr., now the chief scientific officer at Bristol-Myers Squibb.Lynch picked up the story from there.“At the time our treatment of lung cancer was based on chemotherapy which helped patients live longer, but didn’t give the dramatic results we were looking for,” he said.But a new possibility existed in the form of drugs inhibiting EGFR, a protein involved in cancer growth. The drugs were most effective in patients whose EGFR displayed a particular genetic mutation. Given the unusual nature of Olson’s case — she was relatively young, at 45, and a nonsmoker — Lynch thought she fit the profile of a patient who might respond to the treatment.Early results were not promising, and Olson was told she had only a few months to live. But Lynch then learned of a new clinical trial in patients whose lung cancer contained a mutation in the ALK gene, which Olson’s tumor had tested positive for.  The new therapy, crizotinib, was approved by the FDA soon after; Olson was only the fourth patient in the world to receive it. Related HUBweek panel considers implications of wider AI role in decision-making When machines rule, should humans object? “I started feeling better within days,” Olson said. “When I came back after my next scan, Tom was grinning from ear to ear. He said, ‘This is the best news I’ve given any patient in months.’”Insights from immuno-oncology research hold promise for the treatment of other disease, the experts said. Cancer immunotherapies work by modulating pathways that normally keep the brakes on the immune system to prevent the body from attacking itself, a phenomenon known as autoimmunity. Cancer immunotherapies block these pathways and take the brakes off the immune system.“There is unrealized potential for modulating these same pathways to apply these brakes and develop therapies for autoimmune diseases like rheumatoid arthritis and inflammatory diseases like Crohn’s disease,” said Arlene Sharpe, George Fabyan Professor of Comparative Pathology and co-director of the Evergrande Center for Immunologic Diseases at HMS.While Olson’s story was inspiring, the panel also addressed pitfalls and challenges in cancer advances. A major one is that most patients become resistant to the drugs that initially control their disease, making it imperative that new and stronger treatments emerge. Olson, a 12-year survivor, said that she is now on her third course of treatment.“Acquired resistance is tremendously important,” said Alice Shaw, associate professor of medicine at HMS and Paula O’Keeffe Endowed Chair of Thoracic Oncology at MGH. “Maybe 20 percent of patients with lung cancer will have mutations in EGFR, ALK or other genes, making them good candidates for targeted therapies. But they typically start to develop resistance within 24 months. We need to understand that resistance in order to identify new treatments that are effective in resistant patients, as we did in Linnea’s case.”Lynch pointed out the need to fast-track promising drugs. The four-year period crizotinib needed was relatively fast, but “some patients don’t have the four years to wait.”After the panel discussion, an audience member asked about cost of treatment. Olson noted that she was fortunate to have health care, because her treatment would have come to around $14,000 per month. For those without coverage the options are less clear, a problem Lynch addressed as a pharmaceutical executive.“The industry needs to show that we are providing value,” he said. “You’re either helping people live longer or live better, and you have to be doing that in a way that can be afforded by the resources of the country you’re working in. The balance of value will be the great challenge for the industry as we move forward.”last_img read more


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first_imgTake it all on boardThe bottom line is that when your customers build solutions for extreme or non-traditional environments, the onus is on you to deliver. Working with us, you can create connected, secure, rugged maritime solutions that can withstand extreme heat or cold, oil and dust plus the shock and vibration of ship’s engine rooms and other challenging environments.I believe that the marine-grade PowerEdge XR2 is the perfect building block for your rugged OEM maritime solutions, and would love to hear your reactions and questions.Come meet the Dell EMC OEM Crew and experience the PowerEdge XR2 at SMM Hamburg, 4-7 September, Admiral’s Club Lounge, Hall B4.To learn more about Dell EMC OEM, visit: www.dellemc.com/oemVisit DellEMC.COM/XR2 for all the latest XR2 product information. Keep in touch. Follow us on Twitter @etienne_mary and @DellEMCOEM, and join our LinkedIn OEM & IoT Solutions Showcase page here. Are you creating solutions for the maritime or offshore industry outside of the traditional data centre? Do you need to comply with industry-specific certifications, such as Marine IEC60945 or DNV GL standards?Do your customers need to access applications and data anytime, anywhere? Maybe your solutions are operating in the ship’s engine room with the challenge of limited space, oily conditions and extreme temperatures? Perhaps, you’re running naval surveillance operations while having to contend with vibrations caused by waves and high winds?The PowerEdge XR2 has earned its sea legsIf you said yes to any of these questions, you’ll most definitely be interested in the latest marine-certified addition to the Dell EMC OEM PowerEdge family – the XR2, which offers industry-first security features and enhanced systems management.Part of our latest family of 14th generation servers, the good news is that the rugged XR2 has now earned its sea legs with flying colours. You’ll be pleased to hear that multiple configurations have been extensively tested to meet exacting IEC60945 standards and are fully certified for DNV GL.The whole nine yardsSome people may wonder, why do you need a server at sea? The answer is simple. Without a server, you have no way of filtering data, making calculations on the fly, or conducting analytics at the edge. Everything must go back to the data centre, resulting in delays, possible security concerns and negative impact to cost, bandwidth, latency and storage. The good news is that in all these scenarios, the XR2 rises beautifully to the challenge.Light, tough and resistantThis little beauty measures just 52.5 cm (20.67 inches) rack depth and is lightweight at a maximum weight of 13kg (28lbs) so it can certainly fit in close quarters, where there’s no room to swing the proverbial cat. This is ideal for naval vessels, like patrol boats, multi-purpose frigates and amphibious ships, where you can’t use a standard-sized server due to space limitations or tough conditions, but you still need reliability and a lot of compute power, close to the action.No need to batten down the hatchesThe XR2 is resistant to shock and vibration as well as being capable of operating in temperatures of up to 45 degrees C° (113F°). In fact, this little toughie can tolerate 55 degrees C° for up to eight hours. It also has optional, rugged sliding rails for installation in standard four-post racks or in transit cases.Running a tight shipIn addition to the standard PowerEdge security features, a common access card reader on the XR2 provides additional authentication. All you need do is simply remove the common access card reader and the server is immediately rendered useless with all the data automatically encrypted. As the saying goes, a picture paints a thousand words so let’s look at a couple of real-world examples.Plain sailingOne customer offers a VoIP-based switching solution for naval communication, delivering future-ready voice and data communications. In this instance, all of the switching functions are implemented in software, hosted on the Dell EMC PowerEdge XR2 and Dell EMC Storage Virtual Rack MD3 OEM platforms.In another use case, an energy services company built a satellite communications solution for drilling firms in remote harsh environments. The PowerEdge was chosen to cope with severe environmental requirements with the customer saying that it provided ‘outstanding quality’ in the field. Prior to choosing Dell EMC, the energy services supplier’s solution was with a white box provider that had suffered outages because of jarring transportation, dust and extreme temperatures.last_img read more


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first_imgSoVerNet announces that it is nowproviding high-speed Internet business access to two more Vermontcommunities: Randolph and Saint Albans.With the introduction of SoVerNet Symmetric Digital Subscriber Line orSDSL service to Randolph and Saint Albans, businesses within thegeographic limits of the technology now have high-speed connectivity tothe Internet at speeds far superior to those provided by dial-up Internetaccess.SoVerNet’s high-speed broadband service is available at speeds between160K and 1,544K. Customers are required to purchase a dedicated data lineover which the service is provided. The customer may also need topurchase a modem, and, a router depending upon their networking needs.The service is fully monitored 24/7 for reliability. Set-up time takes 2- 3 weeks from time of order to turn-up.SoVerNet has a booklet on SDSL services which is available onrequest. Businesses interested in purchasing SoVerNet high-speedbroadband or obtaining further information can do so by visiting the webpage www.sover.net/services/business.html(link is external) or by contacting the following:Randolph businesses call: Mason Alling 802-861-9012.St. Albans’ businesses call: Nikki Rivolta 802-861-9011.SoVerNet, now Vermont’s largest, statewide, locally-owned, IntegratedCommunications Provider, is headquartered in Bellows Falls.last_img read more


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first_imgSign up for Long Island Press’ email newsletters here. Sign up for home delivery of Long Island Press here. Sign up for discounts by becoming a Long Island Press community partner here.,Sign up for Long Island Press’ email newsletters here. Sign up for home delivery of Long Island Press here. Sign up for discounts by becoming a Long Island Press community partner here.,Sign up for Long Island Press’ email newsletters here. Sign up for home delivery of Long Island Press here. Sign up for discounts by becoming a Long Island Press community partner here. For more Long Island Serial Killer coverage visit longislandpress.com/tag/long-island-serial-killer Sign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York Suffolk County police plan to release additional photos of a belt recovered in the unsolved Gilgo Beach murder investigation, authorities announced a week before the 10-year anniversary of the case.Police said the photos will be released at gilgonews.com, the website the department launched in January as a platform for background information and updates on the case, but did not say exactly when the new photos would be released.“We are hopeful this photo will bring someone forward with information about its origin,” Suffolk County Police Commissioner Geraldine Hart has said of the first photo of the belt released earlier this year.Police previously disclosed the evidence — the first new investigatory detail the department shared since the remains were found along Ocean Parkway in 2010 an ’11 — in January on the same day that Netflix released a trailer for Lost Girls, a movie about the case. The same day, police also launched their new website and announced they were approved to use genetic genealogy to put names to unidentified victims — a development that led to the identification of victim Valerie Mack in May.The new evidence was a black leather belt embossed with the half-inch initials “HM” or “WH” in light blue lettering found at an unspecified victim’s dump site, police said. Investigators believe the belt was handled by the killer and didn’t belong to any of the victims, but they declined to release the belt size.Police were searching for Shannan Gilbert, a New Jersey woman reported missing in May 2010 from Oak Beach, when they discovered 10 sets of human remains—half of whom were also identified as escorts — along Ocean Parkway between December 2010 and April 2011. Gilbert was later found dead, but police and medical examiners have suggested she may have drowned in a marsh — although her family insists she was murdered.Dec. 11 is the anniversary police finding victim Melissa Barthelemy, one of four young women found nearby one another in Gilgo Beach — a discovery that marked the first time Suffolk police confirmed they are looking for a serial killer since dubbed the Long Island Serial Killer.Related Story: Did Police Name A Suspect in The Long Island Serial Killer Case?Related Story: Who is The Girl With The Peach Tattoo?Related Story: Questions Remain in Long Island Serial Killer CaseRelated Story: Red Herrings Among Tips in Long Island Serial Killer Caselast_img read more


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first_imgThose goals are only possible because drugmakers have agreed to manufacture large supplies of their vaccines even before they know whether they work in order to save time.”The federal government has put more than one egg in the basket,” Fauci said. “We have a pretty comprehensive portfolio that’s going to subsequently be going into clinical trials.”He said there might be an indication that at least one vaccine works and is safe by year end.”I’m cautiously optimistic that we will have a vaccine that’s effective enough to get approved,” he said. That will not happen because of any pressure to have a vaccine available in time for the Nov. 3 presidential election, he said. Health regulators have promised “they are not going to let political considerations interfere” with the need to deliver a safe COVID-19 vaccine, Fauci said.Fauci’s interview with Reuters came on the same day Trump said in an interview with Fox News that the virus is “going away. It will go away like things go away.”Fauci offered a more mixed assessment, saying some parts of the country had done well in containing the spread of the virus, while others were “on fire.””I hope, and feel it’s possible, that by the time we get through 2021 and go around for another cycle that we’ll have this under control,” he said.The United States is committed to spending billions of dollars on vaccines being produced by companies including Johnson & Johnson, Moderna Inc, Pfizer Inc , Novavax Inc and Sanofi SA, employing a variety of technologies.Fauci said he did not favor one approach over any other.”All of them look pretty good,” he said. “The proof of the pudding is the randomized placebo controlled trial.” Drugmakers will likely have tens of millions of doses of coronavirus vaccines in the early part of next year, Anthony Fauci, the top US infectious diseases official, said in a Reuters interview on Wednesday, offering a more conservative view of the ramp up than some Trump administration officials.Fauci said there could be a billion vaccine doses available by the end of 2021, and that he is hopeful the world could get past the pandemic that has claimed more than 700,000 lives worldwide by then, with the help of a vaccine.US Secretary of Health and Human Services Alex Azar said last month the US would have hundreds of millions of vaccine doses by early in 2021.center_img Topics :last_img read more


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first_imgAt least 22 activists were abducted during the period. Nine were eventually returned, and 13 remain missing more than two decades later.On Aug. 25, 1998, the Armed Forces (ABRI) – since renamed the TNI – honorably discharged then-Lt. Gen. Prabowo Subianto and removed two Kopassus officers from active duty as punishment for their suspected roles in the abduction of prodemocracy activists.In 1999, the Jakarta High Military Court sentenced the commander of Tim Mawar and all ten of its members to between 12 and 22 months in prison. Five of the members were to be stripped of their positions and discharged from the TNI, including Yulius.However, after they appealed the court’s verdict, none were dismissed.In 2016, four Tim Mawar members – Dadang, Yulius, Fausani Syahrial Multhazar and Nugroho Sulistyo Budi – were promoted to strategic posts in the government.Read also: How democracy diesYulius was promoted to head of the Riau Islands branch of the State Intelligence Agency (BIN), while Dadang was promoted to a position in the BNPT. The appointment of Yulius and Dadang to the Defense Ministry came after Prabowo appointed Chairawan Kadarsyah Kadirussalam Nusyirwan, the former commander of Tim Mawar, as one of the ministry’s special assistants in December of last year.Rights activists lambasted the appointment of the military generals to the positions, with Amnesty International Indonesia executive director Usman Hamid saying that Jokowi had violated his own promises to resolve past human rights abuses in the country.“Instead of bringing the suspects of past human rights abuses to court, the government has placed them in power. Those who are involved in human rights violations should not be given leadership positions in either the military or other structural positions in the government,” Usman said.He demanded that the government immediately investigate past human rights violations, including the cases of the disappeared activists. The government’s lack of commitment in settling the cases, Usman said, would only prolong the culture of impunity.Topics : According to the decree, a copy of which was obtained by The Jakarta Post, former Tim Mawar member Brig. Gen. Dadang Hendrayudha, who previously served as the head of the general affairs bureau at the National Counterterrorism Agency (BNPT) secretariat, will serve as the Defense Ministry’s director general for defense potential.Brig. Gen. Yulius Selvanus, another former member of Tim Mawar who currently serves at the Praja Vira Tama military command post (Korem) in Sorong, Papua, has been appointed to helm the ministry’s strategic defense installation body (Bainstrahan).Read also: Indonesian Military deployed for coronavirus fightThe notorious Tim Mawar was implicated in a series of kidnappings and disappearances of prodemocracy activists between 1997 and 1998, at the tail end of the New Order regime, when now-Defense Minister Prabowo Subianto was heading Kopassus. President Joko “Jokowi” Widodo has appointed six military officers to strategic posts within the Defense Ministry, including two former members of the infamous Tim Mawar (Rose Team) of the Army’s Special Forces (Kopassus), which was implicated in the notorious forced disappearances of activists in the late 1990s.Defense Ministry spokesperson Brig. Gen. Djoko Purwanto confirmed the appointments – stipulated by a presidential decree on Wednesday – but said the administrative process was still ongoing.“The inauguration will take place following the approval of the Indonesian Military [TNI] commander,” Djoko said on Friday, referring to TNI commander Air Chief Marshal Hadi Tjahjanto.last_img read more


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first_img A statement issued on behalf of Williamson was released by Refuel Performance Management on Sunday following the Magpies’ 3-0 defeat at the King Power Stadium which left them in serious danger of relegation. Dutch full-back Daryl Janmaat was also dismissed to leave interim boss Carver fuming. Williamson said in the statement: “I would like to take this opportunity to apologise to the Newcastle United supporters and my fellow team-mates for getting sent off during yesterday’s game. Press Association Mike Williamson has apologised for his sending-off for Newcastle at Leicester on Saturday but denied his manager John Carver’s claim that his dismissal was deliberate. Carver’s record since taking charge at St James’ Park is dismal, having overseen just two wins in 17 games. But Carver – despite increasing speculation over his future – insists he will not hide and wants his players to follow suit. He said: “If someone was having a go at me I would want to prove a point – and I have had a lot of that over the last few weeks. I ain’t crumbled, I ain’t disappeared. I still come out here and stand up to be counted. It is important. I am not a shirker. “I am an honest, straight guy and face it head-on. The day I don’t do that, I may as well forget it. The players have to be the same. They have to face up. “If they don’t grow up and take it on the chin – go and hide behind a post. That is how seriously I feel about it.” Williamson was the chief target of Carver’s ire, b ut Daryl Janmaat later followed him for earning a second booking in injury time and only Jack Colback and Tim Krul escaped Carver’s criticism. The frustration of fans was clear in the banner they held up during the game criticising the club and when they booed players at the final whistle. Defender Paul Dummett said: “I am a fan just like they are and I feel the way they feel – very frustrated. We’re massively frustrated and we need to put it right next week.” Leicester are still a point behind Newcastle but the difference in mood between the two clubs was stark. Despite their midweek setback against Chelsea, the Foxes have been a team transformed over the past month and, after five wins in six, they seem to be heading in the opposite direction. Any suggestion that last week’s “ostrich” spat between Leicester manager Nigel Pearson and a journalist might have unsettled the Foxes was emphatically dismissed. With such spirit, Leicester are confident of survival but three games still remain and the job is not yet done. Ulloa told the club’s website, www.lcfc.com: “We knew we had four finals, now we have three. “But it was a very important result, and not just the result – it was also important the feeling we had. We had control of the game. “But we need to think about the next game now. If we can win it is three important points for us.” “There was absolutely no intent to hurt (Leicester’s) Jamie (Vardy) or get sent off, but I recognise I should have been more composed and measured in my determination to win the ball. Unfortunately, it did the one thing that I never wanted to do, and that was hurt the team. “Moving forward, I will do whatever I can to help my team-mates prepare for the next two games and fight to get back into the team when I’m next available. “I’ve had the honour to play for Newcastle United for five years now, and I can genuinely say that I feel privileged to play for this football club. I would never do anything intentionally to hurt the team or its supporters.” Carver could not disguise his anger at his players after Saturday’s defeat, which leaves them just two points ahead of bitter rivals Sunderland in 18th, who have a game in hand. The loss was Newcastle’s eighth in a row. ”I thought he meant it,” Carver said in his post-match press conference. ”When the ball went onto that left-hand side, my first reaction, five yards before making the tackle was, ‘Don’t do it’ – and he did it. ”Vardy was off the pitch, Willo was off the pitch, the ball was off the pitch. There was no need to do it. I am not accepting that, especially in the situation we are in.” Asked why Williamson might have done something like that on purpose, Carver said: ”I don’t really know. It was just my thought when it happened. I thought he meant that and I have told him so. I have actually said this to his face.” last_img read more


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first_img The 21-year-old’s journey from squad player to talisman at White Hart Lane has been one of the stories of the season and he provided one final reminder of his quality during a largely mundane encounter at Goodison Park. The PFA Young Player of the Year headed Eric Dier’s 24th-minute cross beyond Tim Howard in a 1-0 victory which lifted Spurs up to fifth, above Everton’s local rivals Liverpool. Harry Kane rounded off his memorable breakthrough campaign with his 31st Tottenham goal of the season as Mauricio Pochettino’s men sealed fifth spot and a place in next term’s Europa League. While the red half of Merseyside was undoubtedly experiencing a more grim final afternoon at Stoke, there was little cheer for the Blues either. They missed out on the top 10 just one year on from their fifth-placed finish in Roberto Martinez’s maiden campaign. This was the 57th game Spurs had played this season, with Everton taking to the pitch for the 51st time – but it was the visitors who looked less fatigued in the opening exchanges. Their attacking players darted between the lines with ease and after Erik Lamela had fired over, Ryan Mason collected a one-two from Christian Eriksen before running into Phil Jagielka, with referee Jon Moss uninterested in his half-hearted penalty appeals. Lamela was the next to burst into the box after Eriksen fed him following an error from home debutant Brendan Galloway, yet Howard’s right hand prevented the Argentinian from finding the far corner. Moments later Kevin Mirallas broke behind Tottenham’s back line only to drill his opportunity straight into Hugo Lloris’ body. The Belgian forward did better with a self-created chance when he blasted narrowly over after teeing himself up with a couple of touches on the edge of the area. However, Spurs would claim a deserved lead thanks to yet another goal from their number 18. Dier’s first-time cross from the right flank was inviting and Kane stooped to guide his header beyond Howard and into the far corner for his first goal in five matches. Everton stirred from their end-of-season slumber somewhat to test Lloris at the end of the first period as a Mirallas effort landed on the roof of the net and Seamus Coleman’s cross was pushed away by the Frenchman. Press Association And the Toffees started strongly after the break as half-time substitute Muhamed Besic steered a long-range try wide, Leon Osman volleyed off target and Galloway almost broke beyond Lloris. That period was short-lived, though, as Spurs settled back into their pattern of dominating possession while their lacklustre hosts ambled around the pitch. Kane’s blushes were then spared by the offside flag as he headed a simple chance wide, after Eriksen clipped the ball into him at the end of a sustained spell of Spurs possession. The rise to prominence of Kane, who also netted on his senior England debut in March, has made him a household name but there were chuckles when it was announced Harry ‘Keane’ was being substituted in the closing stages. There was no mispronunciation of Sylvain Distin’s name as the centre-back appeared for a farewell cameo moments earlier, but his arrival, and the Liverpool result, produced the only cheers of the afternoon from the home faithful. last_img read more


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first_imgAccording to Trump administration data released Tuesday, nearly one million people were taken into custody over the past 12 months for trying to cross illegally.The number of arrests at the border is the highest in the U.S. in the past twelve years.Mark Morgan, the acting commissioner of U.S. Customs and Border Protection, said that more than 52,000 migrants were taken into custody in September at U.S. ports of entry and between them.It was a decline of 18 percent from August.Furthermore, he said it was a decline of 18 percent from August.Overall, U.S. border authorities made more than 975,000 arrests during 2019, according to the Trump administration’s latest data.“These are numbers no immigration system in the world is designed to handle,” Morgan said.Arrests by U.S. border agents reached an all-time high of 1.6 million in 2000, but the Department of Homeland Security officials insist that the migration wave they faced this year is unlike anything in the past.last_img read more


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first_imgTWO-TIME Olympic champion Shelly-Ann Fraser-Pryce has mended fences, in a manner of speaking, with lifelong track club MVP.At the end of the Olympic Games in Rio de Janeiro, Brazil, where Fraser-Pryce just missed out on becoming the first woman in history to win three consecutive gold medals over the 100-metre sprint at the games, it was rumoured that the athlete was leaving the camp.The decision, it was said, sparked from an injury the athlete felt was poorly handled by the Stephen Francis-led MVP.Francis, himself, later confirmed the rift, saying Fraser-Pryce did not feel the club had her best interest at heart and would be moving on. Despite the injury, Fraser-Pryce performed creditably, earning a pain-racked bronze medal.At the start of the track season this year, it was said that Fraser-Pryce was training in St Elizabeth with former MVP coach Reynaldo Walcott. However, it seems the athlete has had a change of heart.Fuelling the rumour was the presence of former teammates at MVP, Kaliese Spencer and Christine Day. The two are now training with Walcott after spending a year with the Bert Cameron-led Cameron Blazers.(Sportsmax.com)last_img read more